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KMID : 0369820050350060445
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 6 p.445 ~ p.451
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Preparation and Dissolution Profiles of Controlled Release Formulations Containing Tamsulosin Hydrochloride
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윤재남/Yun JN
김정수/김동우/이계원/지웅길/Kim JS/Kim DW/Lee GW/Jee UK
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Abstract
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As a selective α1A?adrenoreceptor antagonist, tamsulosin has been used clinically for urinary obstructed patients with benign prostatic hyperplasia. The single and multi-layered pellets containing tamsulosin hydrochloride were prepared in an effort to control the drug release, avoiding dose-dependent side effects of tamsulosin hydrochloride upon oral administration. The drug release from multi-layered pellets was substantially controlled, compared with single layered pellets. The drug release from coated pellets with single or multi layer was affected by the nature of coating agent, the percentage of coating level and the presence of hydrophilic material in coating layer. In conclusion, the controlled release oral delivery system using multi-layered pellet is very useful for tamsulosin hydrochloride, resulting in improvement of patient compliance and therapeutic drug levels for a longer period of time.
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KEYWORD
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Tamsulosin hydrochloride, Controlled release, Single and multi-layered pellet
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